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Takashi Satoh, MD
Associate Professor
1978-1984 Fukusima Prefectural Medical College
1993-1994 Department of Pathology, Georg-August University, Goettingen,Germany (Prof. H. J. Radzun)

Research field:
structure and function of the spleen

Surgical pathology:
hematopathology
soft tissue & bone tumor

e-mail: tsatoh@iwate-med.ac.jp

Research interests
Structure and function of the spleen
The white pulp and marginal zone constitute the immunologicaly active compartment of hte spleen. In the white pulp, there are two distinct regions, the periarteriolar lymphoid sheath (PALS) and the lymph follicle (LF). The marginal zone is located between the white pulp and the red pulp. The basic framework of the white pulp and marginal zone consists of reticulum cells and reticulin fibers. A distinct microenvironment is formed in the reticular framework of the PALS, LF and marginal zone, respectively. Immunohistochemically, the reticular framework of the PALS and LF is specialized into heterogenous components and the antigenic heterogeneity of the reticular framework may induce the segregation of the lymphoid subclasses in lymphocyte homing into the PALS and LF.
Large


Confocal laser scanning microscopy of the white pulp of the human spleen.

Representative publications
Yashima A, Maesawa C, Tarusawa M, Satoh T, Oikawa H, Ishida Y, Satoh M, Yamada T and Masuda T. Consensus strategy of real-time quantitative polymerase chain reaction for the detection of minimal
residual disease In non-Hodgkin lymphoma. Leuk Res 27: 925-934, 2003

Ohgi S, Ehara S, Satoh T, Kato M, Shimosegawa K and Ishida Y. Spontaneous regression of malignant lymohom of lumbar spine. Skeletal Radiol 31: 99-102, 2002

Satoh T, Hemmerlein B, Zschunke F, Radzun HJ. In situ detection of human monocyte/macrophage serine esterase 1 mRNA expression in human tissues. Pathobiology 67: 158-162, 1999.

Satoh T, Sato T and Takeda R. Interdigitating cells are resistant cells against radiation-Induced apoptosis. J Iwate Med Ass 50 (Suppl): 645-652, 1999.

Sato S, Masuda T, Oikawa H, Satoh T, Suzuki Y, Takikawa Y, Yamazaki K, Suzuki K and Sato S. Primary hepatic lymphoma associated with primary biliary cirrhosis. Am J Gastroenterol 94: 1669-1673, 1999.

Sakuma T, Satoh T, Takeda R, Monma N and Tomichi. Proliferation of follicular dendritic cells (FDCs) without expression of HLA-DR antigen in angioimmunoblastic T-cell lymphoma (AILD) : Immunohistochemical study. Dendritic cells 8:47-50, 1998.

Sato S, Masuda T, Satoh T and Suzuki K. Immunohistochemical study of tumor necrosis factor-alpha in acute liver Injury Induced by Propionibacterium canes and lipopolysaccharide In rats. Hepatol Commun, 6: 179-190, 1997.

Satoh T, Takeda R, Oikawa H and Satodate R. Immunohistochemical and structural characteristics of the reticular framework of the white pulp and marginal zone in the human spleen. Anat Rec 249: 486-494, 1997

Muro-oka G, Satoh T, Masuda T and Sakuma T. Expression and localization of ossification-related factors in fracture healing: comparative study of experimental union and non-union models. J Orthop Sci 1: 193-202, 1996


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